Function
A Disintegrin And Metalloproteinase (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM family members are numbered.
- ADAM10 cleaves ephrin.
- ADAM13 details are in Molecular Playground/ADAM13.
- ADAM17 (TACE or TNF-α converting enzyme) processes the tumor necrosis factor-α.
- ADAM33 is implicated in asthma.
- ADAMTS is ADAM with thrombospondin motifs[1].
- ADAMTS1 has anti-angionenic activity.
- ADAMTS4 and ADAMTS5 are involved in the degradation of aggrecan.
- ADAMTS13 cleaves Von Willebrand Factor involved in blood clotting.
[2]
Disease
ADAM inhibitors are used in anti-cancer therapy. ADAM10 is a therapeutic target for cancer and inflammation [3]. ADAM17 is a therapeutic target for multiple diseases [4].ADAM33 is implicated in asthma. ADAMTS13 cleaves von Willebrand factor involved in blood clotting. ADAM33 is a therapeutic target for asthma [5].
3D Structures of A Disintegrin And Metalloproteinase
A Disintegrin And Metalloproteinase 3D structures
