Alpha-glucosidase

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spinqualitylabelsall models Structure of yeast isomaltase complex with α-D-glucose and Ca+2 ion (green) (PDB code 3a4a). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Structural highlights 4 3D structures of α-glucosidase Function Alpha glucosidase (AGS) or maltase breaks down the 1,4-α bonds in starch or disaccharides to produce glucose. Maltase breaks down maltose. Isomaltase or sucrase-isomaltase or oligo-1,6-glucosidase breaks the 1,6 bond.[1] Maltase-glucoamylase has important role in glucose production. It hydrolize linear alpha-1,4-linked oligosaccharides[2]. For details see Sucrase-isomaltase. See also Kennedy research and Carbohydrate Metabolism. Disease AGS deficiency is the cause of Pompe Disease. AGS inhibitors are used as anti-diabetic drugs and can potentially prevent the fusion of HIV and hepatitis B virus to cells. Structural highlights (PDB code 3a4a).[3] Water molecules shown as red spheres. . 3D structures of α-glucosidase Alpha-glucosidase 3D structures

References

1. ↑ Gloster TM, Turkenburg JP, Potts JR, Henrissat B, Davies GJ. Divergence of catalytic mechanism within a glycosidase family provides insight into evolution of carbohydrate metabolism by human gut flora. Chem Biol. 2008 Oct 20;15(10):1058-67. Epub 2008 Oct 9. PMID:18848471 doi:10.1016/j.chembiol.2008.09.005
2. ↑ Ren L, Qin X, Cao X, Wang L, Bai F, Bai G, Shen Y. Structural insight into substrate specificity of human intestinal maltase-glucoamylase. Protein Cell. 2011 Oct;2(10):827-36. Epub 2011 Nov 6. PMID:22058037 doi:10.1007/s13238-011-1105-3
3. ↑ Yamamoto K, Miyake H, Kusunoki M, Osaki S. Crystal structures of isomaltase from Saccharomyces cerevisiae and in complex with its competitive inhibitor maltose. FEBS J. 2010 Oct;277(20):4205-14. doi: 10.1111/j.1742-4658.2010.07810.x., Epub 2010 Aug 31. PMID:20812985 doi:10.1111/j.1742-4658.2010.07810.x