1u2w

Structural highlights

Function

CADC_STAAU Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Binds 2 metal ions per subunit. Metal binding to the N-terminal regulatory site causes the repressor to dissociate from the DNA.^{[1] [2] [3] [4] [5]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Endo G, Silver S. CadC, the transcriptional regulatory protein of the cadmium resistance system of Staphylococcus aureus plasmid pI258. J Bacteriol. 1995 Aug;177(15):4437-41. PMID:7543476
2. ↑ Sun Y, Wong MD, Rosen BP. Role of cysteinyl residues in sensing Pb(II), Cd(II), and Zn(II) by the plasmid pI258 CadC repressor. J Biol Chem. 2001 May 4;276(18):14955-60. Epub 2001 Feb 14. PMID:11278706 doi:http://dx.doi.org/10.1074/jbc.M010595200
3. ↑ Wong MD, Lin YF, Rosen BP. The soft metal ion binding sites in the Staphylococcus aureus pI258 CadC Cd(II)/Pb(II)/Zn(II)-responsive repressor are formed between subunits of the homodimer. J Biol Chem. 2002 Oct 25;277(43):40930-6. Epub 2002 Aug 9. PMID:12176999 doi:http://dx.doi.org/10.1074/jbc.M206536200
4. ↑ Busenlehner LS, Apuy JL, Giedroc DP. Characterization of a metalloregulatory bismuth(III) site in Staphylococcus aureus pI258 CadC repressor. J Biol Inorg Chem. 2002 Apr;7(4-5):551-9. Epub 2002 Feb 8. PMID:11941514 doi:http://dx.doi.org/10.1007/s00775-001-0336-9
5. ↑ Kandegedara A, Thiyagarajan S, Kondapalli KC, Stemmler TL, Rosen BP. Role of bound Zn(II) in the CadC Cd(II)/Pb(II)/Zn(II)-responsive repressor. J Biol Chem. 2009 May 29;284(22):14958-65. Epub 2009 Mar 13. PMID:19286656 doi:10.1074/jbc.M809179200