2yu0

Structural highlights

Function

[IFI5B_MOUSE] May act as a transcriptional regulator in the myeloid lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Pyrin domain

References

1. ↑ Dermott JM, Gooya JM, Asefa B, Weiler SR, Smith M, Keller JR. Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation. Stem Cells. 2004;22(5):832-48. PMID:15342947 doi:http://dx.doi.org/10.1634/stemcells.22-5-832
2. ↑ Asefa B, Dermott JM, Kaldis P, Stefanisko K, Garfinkel DJ, Keller JR. p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation. FEBS Lett. 2006 Feb 20;580(5):1205-14. Epub 2006 Jan 20. PMID:16458891 doi:http://dx.doi.org/10.1016/j.febslet.2006.01.032