3taz

Structural highlights

Function

NURA_PYRFU Involved in DNA double-strand break (DSB) repair (PubMed:18957200). Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (PubMed:18957200). Exhibits 5' endonuclease activity and both 5' and 3' exonuclease activities (PubMed:22064858).^{[1] [2]}

References

1. ↑ Hopkins BB, Paull TT. The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break. Cell. 2008 Oct 17;135(2):250-60. PMID:18957200 doi:10.1016/j.cell.2008.09.054
2. ↑ Chae J, Kim YC, Cho Y. Crystal structure of the NurA-dAMP-Mn2+ complex. Nucleic Acids Res. 2011 Nov 7. PMID:22064858 doi:10.1093/nar/gkr999