7sqk

Structural highlights

Function

[HAUS2_HUMAN] Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.^{[1] [2]}

References

1. ↑ Uehara R, Nozawa RS, Tomioka A, Petry S, Vale RD, Obuse C, Goshima G. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6998-7003. doi:, 10.1073/pnas.0901587106. Epub 2009 Apr 14. PMID:19369198 doi:http://dx.doi.org/10.1073/pnas.0901587106
2. ↑ Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R, Habermann B, Tagliaferro A, Poser I, Hutchins JR, Hegemann B, Pinchev D, Buchholz F, Peters JM, Hyman AA, Gingras AC, Pelletier L. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr Biol. 2009 May 26;19(10):816-26. doi: 10.1016/j.cub.2009.04.033. Epub 2009, May 7. PMID:19427217 doi:http://dx.doi.org/10.1016/j.cub.2009.04.033