8qt5

Structural highlights

Function

14336_ARATH Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes (By similarity). Specific negative regulator of slow-vacuolar (SV) ion channel. Mediates F-actin dynamics possibly through inhibiting ADF1 phosphorylation (PubMed:26345162). Negative regulator of freezing tolerance that modulates cold-responsive C-repeat-binding factors (CBF) DREB1A and DREB1B proteins stability by facilitating their ubiquitin-mediated degradation when activated by CRPK1-mediated phosophorylation in freezing conditions; this processus is counteracted by B1L (PubMed:28344081, PubMed:31297122).^{[1] [2] [3] [4]} BZR1_ARATH Transcriptional repressor that binds to the brassinosteroid (BR) response element (BRRE) 5'-CGTG(T/C)G-3' in gene promoter. Regulates positively the brassinosteroid-signaling pathway (PubMed:33324437). Mediates downstream growth responses and negative feedback regulation of brassinosteroid biosynthesis. Promotes growth. Modulates ovule initiation and development by monitoring the expression of genes related to ovule development (e.g. HLL, ANT, and AP2). Regulates negatively the abscisic acid (ABA) signaling pathway during the post-germination stage (PubMed:33324437).^{[5] [6] [7]}

References

1. ↑ Latz A, Becker D, Hekman M, Müller T, Beyhl D, Marten I, Eing C, Fischer A, Dunkel M, Bertl A, Rapp UR, Hedrich R. TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins. Plant J. 2007 Nov;52(3):449-59. PMID:17764516 doi:10.1111/j.1365-313X.2007.03255.x
2. ↑ Zhao S, Zhao Y, Guo Y. 14-3-3 λ protein interacts with ADF1 to regulate actin cytoskeleton dynamics in Arabidopsis. Sci China Life Sci. 2015 Nov;58(11):1142-50. PMID:26345162 doi:10.1007/s11427-015-4897-1
3. ↑ Liu Z, Jia Y, Ding Y, Shi Y, Li Z, Guo Y, Gong Z, Yang S. Plasma Membrane CRPK1-Mediated Phosphorylation of 14-3-3 Proteins Induces Their Nuclear Import to Fine-Tune CBF Signaling during Cold Response. Mol Cell. 2017 Apr 6;66(1):117-128.e5. PMID:28344081 doi:10.1016/j.molcel.2017.02.016
4. ↑ Chen T, Chen JH, Zhang W, Yang G, Yu LJ, Li DM, Li B, Sheng HM, Zhang H, An LZ. BYPASS1-LIKE, A DUF793 Family Protein, Participates in Freezing Tolerance via the CBF Pathway in Arabidopsis. Front Plant Sci. 2019 Jun 26;10:807. PMID:31297122 doi:10.3389/fpls.2019.00807
5. ↑ He JX, Gendron JM, Sun Y, Gampala SS, Gendron N, Sun CQ, Wang ZY. BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses. Science. 2005 Mar 11;307(5715):1634-8. doi: 10.1126/science.1107580. Epub 2005 , Jan 27. PMID:15681342 doi:http://dx.doi.org/10.1126/science.1107580
6. ↑ Huang HY, Jiang WB, Hu YW, Wu P, Zhu JY, Liang WQ, Wang ZY, Lin WH. BR signal influences Arabidopsis ovule and seed number through regulating related genes expression by BZR1. Mol Plant. 2013 Mar;6(2):456-69. doi: 10.1093/mp/sss070. Epub 2012 Aug 22. PMID:22914576 doi:http://dx.doi.org/10.1093/mp/sss070
7. ↑ Wu J, Yan M, Zhang D, Zhou D, Yamaguchi N, Ito T. Histone Demethylases Coordinate the Antagonistic Interaction Between Abscisic Acid and Brassinosteroid Signaling in Arabidopsis. Front Plant Sci. 2020 Nov 25;11:596835. doi: 10.3389/fpls.2020.596835. , eCollection 2020. PMID:33324437 doi:http://dx.doi.org/10.3389/fpls.2020.596835