Cryptochrome

From Proteopedia

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spinqualitylabelsall models Mouse cryptochrome-1 complex with FAD (PDB code 4i6g) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Cryptochrome (Cry) is a flavoprotein associated with the biological clock function. In Drosophila melanogaster it is also involved in blue-light photoreception[1]. Cryptochrome-1 is a circadian clock repressor[2]. For details on cryptochrome 4 see Cryptochrome 4. See also JMS/cryptochrome and Period circadian protein. Disease The absence of Cry resulting in the lack of functional clock system leads to elevated proinflammatory cytokine activation and thus to increase incidence of chronic diseases such as diabetes, obesity and also cancer[3]. 3D Structures of cryptochrome Cryptochrome 3D structures

References

1. ↑ Yoshii T, Todo T, Wulbeck C, Stanewsky R, Helfrich-Forster C. Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons. J Comp Neurol. 2008 Jun 20;508(6):952-66. doi: 10.1002/cne.21702. PMID:18399544 doi:http://dx.doi.org/10.1002/cne.21702
2. ↑ Xu H, Gustafson CL, Sammons PJ, Khan SK, Parsley NC, Ramanathan C, Lee HW, Liu AC, Partch CL. Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus. Nat Struct Mol Biol. 2015 Jun;22(6):476-484. PMID:25961797 doi:10.1038/nsmb.3018
3. ↑ Narasimamurthy R, Hatori M, Nayak SK, Liu F, Panda S, Verma IM. Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12662-7. doi:, 10.1073/pnas.1209965109. Epub 2012 Jul 9. PMID:22778400 doi:http://dx.doi.org/10.1073/pnas.1209965109