Dedicator of cytokinesis protein

From Proteopedia

spinqualitylabelsall models Human dedicator of cytokinesis protein 9 dimer DHR-2 domain (grey and aqua) complex with Cdc42 (green and olive) and GDP (PDB code 2wmn) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Structural highlights 4 3D structures of dedicator of cytokinesis protein Function Dedicator of cytokinesis proteins (DOCK) are guanine-nucleotide exchange factors for Rho-family GTPase. DOCKs are required in cell motility and phagocytosis. DOCK1 is a regulator of cancer metastasis[1]. DOCK2 is a regulator of various immune functions by activating Raz[2]. Disease Mutations in DOCK8 are found in patients diagnosed with an atypical form of hyper-IgE syndrome[3]. Structural highlights (PDB code 2wmn). (GTP-binding protein). Water molecules shown as red spheres. [4]. 3D structures of dedicator of cytokinesis protein Dedicator of cytokinesis protein 3D structures

References

1. ↑ Chiang SK, Chang WC, Chen SE, Chang LC. DOCK1 Regulates Growth and Motility through the RRP1B-Claudin-1 Pathway in Claudin-Low Breast Cancer Cells. Cancers (Basel). 2019 Nov 8;11(11):1762. PMID:31717460 doi:10.3390/cancers11111762
2. ↑ . PMID:355484329
3. ↑ Su HC. Dedicator of cytokinesis 8 (DOCK8) deficiency. Curr Opin Allergy Clin Immunol. 2010 Dec;10(6):515-20. doi:, 10.1097/ACI.0b013e32833fd718. PMID:20864884 doi:http://dx.doi.org/10.1097/ACI.0b013e32833fd718
4. ↑ Yang J, Zhang Z, Roe SM, Marshall CJ, Barford D. Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. Science. 2009 Sep 11;325(5946):1398-402. PMID:19745154 doi:325/5946/1398