Structural highlights
Function
CMGA_HUMAN Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.
Publication Abstract from PubMed
Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for alphavbeta6 and alphavbeta8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.
A stapled chromogranin A-derived peptide is a potent dual ligand for integrins alphavbeta6 and alphavbeta8.,Nardelli F, Ghitti M, Quilici G, Gori A, Luo Q, Berardi A, Sacchi A, Monieri M, Bergamaschi G, Bermel W, Chen F, Corti A, Curnis F, Musco G Chem Commun (Camb). 2019 Nov 22. doi: 10.1039/c9cc08518a. PMID:31755501[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Nardelli F, Ghitti M, Quilici G, Gori A, Luo Q, Berardi A, Sacchi A, Monieri M, Bergamaschi G, Bermel W, Chen F, Corti A, Curnis F, Musco G. A stapled chromogranin A-derived peptide is a potent dual ligand for integrins alphavbeta6 and alphavbeta8. Chem Commun (Camb). 2019 Nov 22. doi: 10.1039/c9cc08518a. PMID:31755501 doi:http://dx.doi.org/10.1039/c9cc08518a
