HIF1α is a subunit of the transcription factor HIF1, together with HIF1β (Loboda, Jozkowicz, and Dulak 2010). HIF1α is part exclusively of HIF1 whilst HIF1β is part of other transcription factors as well as HIF1.
HIF1 is related to glucose metabolism, stimulation of circulation and it was first described in hypoxia conditions, but it is now known that it can be activated also in normoxia situations, acting especially in the polarization of immune cells to more inflammatory phenotypes (O’Neill, Kishton, and Rathmell 2016).
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Structural highlights
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