Structural highlights
Function
DISA_MYCS2 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.[HAMAP-Rule:MF_01438] Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.[HAMAP-Rule:MF_01438][1]
References
- ↑ Zhang L, He ZG. Radiation-sensitive gene A (RadA) targets DisA, DNA integrity scanning protein A, to negatively affect cyclic Di-AMP synthesis activity in Mycobacterium smegmatis. J Biol Chem. 2013 Aug 2;288(31):22426-36. PMID:23760274 doi:10.1074/jbc.M113.464883
