Structural highlights
Function
[H31_HUMAN] [CENPA_CHICK] Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:14563550). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:15870271).[UniProtKB:P49450][1] [2]
References
- ↑ Regnier V, Novelli J, Fukagawa T, Vagnarelli P, Brown W. Characterization of chicken CENP-A and comparative sequence analysis of vertebrate centromere-specific histone H3-like proteins. Gene. 2003 Oct 16;316:39-46. doi: 10.1016/s0378-1119(03)00768-6. PMID:14563550 doi:http://dx.doi.org/10.1016/s0378-1119(03)00768-6
- ↑ Regnier V, Vagnarelli P, Fukagawa T, Zerjal T, Burns E, Trouche D, Earnshaw W, Brown W. CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1. Mol Cell Biol. 2005 May;25(10):3967-81. doi: 10.1128/MCB.25.10.3967-3981.2005. PMID:15870271 doi:http://dx.doi.org/10.1128/MCB.25.10.3967-3981.2005
