8igg

Structural highlights

Function

CHMA_BP201 Self-assembles to forms a proteinaceous shell that encloses the viral DNA and compartmentalizes proteins and DNA during viral infection (PubMed:28082593, PubMed:28813669, PubMed:35922510). This micrometer-scale compartment contains narrow pores and is the site of viral replication, with the proteins involved in DNA replication localized inside (PubMed:28082593, PubMed:28813669, PubMed:35922510). Provides a surface for docking of capsids during packaging (PubMed:28082593, PubMed:28813669). Probably protects the viral genome against host defenses (Probable).^{[1] [2] [3] [4]}

References

1. ↑ Chaikeeratisak V, Nguyen K, Khanna K, Brilot AF, Erb ML, Coker JK, Vavilina A, Newton GL, Buschauer R, Pogliano K, Villa E, Agard DA, Pogliano J. Assembly of a nucleus-like structure during viral replication in bacteria. Science. 2017 Jan 13;355(6321):194-197. doi: 10.1126/science.aal2130. PMID:28082593 doi:http://dx.doi.org/10.1126/science.aal2130
2. ↑ Chaikeeratisak V, Nguyen K, Egan ME, Erb ML, Vavilina A, Pogliano J. The Phage Nucleus and Tubulin Spindle Are Conserved among Large Pseudomonas Phages. Cell Rep. 2017 Aug 15;20(7):1563-1571. doi: 10.1016/j.celrep.2017.07.064. PMID:28813669 doi:http://dx.doi.org/10.1016/j.celrep.2017.07.064
3. ↑ Laughlin TG, Deep A, Prichard AM, Seitz C, Gu Y, Enustun E, Suslov S, Khanna K, Birkholz EA, Armbruster E, McCammon JA, Amaro RE, Pogliano J, Corbett KD, Villa E. Architecture and self-assembly of the jumbo bacteriophage nuclear shell. Nature. 2022 Aug;608(7922):429-435. doi: 10.1038/s41586-022-05013-4. Epub 2022, Aug 3. PMID:35922510 doi:http://dx.doi.org/10.1038/s41586-022-05013-4
4. ↑ Laughlin TG, Deep A, Prichard AM, Seitz C, Gu Y, Enustun E, Suslov S, Khanna K, Birkholz EA, Armbruster E, McCammon JA, Amaro RE, Pogliano J, Corbett KD, Villa E. Architecture and self-assembly of the jumbo bacteriophage nuclear shell. Nature. 2022 Aug;608(7922):429-435. doi: 10.1038/s41586-022-05013-4. Epub 2022, Aug 3. PMID:35922510 doi:http://dx.doi.org/10.1038/s41586-022-05013-4