8ppr

Structural highlights

Function

DSN1_HUMAN Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.^{[1] [2]}

References

1. ↑ Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nat Cell Biol. 2004 Nov;6(11):1135-41. Epub 2004 Oct 24. PMID:15502821 doi:http://dx.doi.org/10.1038/ncb1187
2. ↑ Kline SL, Cheeseman IM, Hori T, Fukagawa T, Desai A. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J Cell Biol. 2006 Apr 10;173(1):9-17. Epub 2006 Apr 3. PMID:16585270 doi:http://dx.doi.org/10.1083/jcb.200509158