Interleukin-1 receptor-associated kinase

Function

Interleukin-1 receptor-associated kinase (IRAK) is a kinase involved in signaling innate immune responses from Toll-like receptors and interleukin-1 receptor-related proteins^[1].

• Interleukin-1 receptor-associated kinase 4 (IRAK4) has scaffold function in myddosome formation ^[2].

Relevance

IRAK4 is involved in early recognition of pathogens and the initiation of inflammation when fighting infection.

Disease

IRAK4 deficiency is a disorder which causes recurrent bacterial infections.