Structural highlights
Disease
IBP7_HUMAN Familial retinal arterial macroaneurysm. The disease is caused by variants affecting the gene represented in this entry.
Function
IBP7_HUMAN Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.[1] [2] C1QR1_HUMAN Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.
References
- ↑ Akaogi K, Okabe Y, Funahashi K, Yoshitake Y, Nishikawa K, Yasumitsu H, Umeda M, Miyazaki K. Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells. Biochem Biophys Res Commun. 1994 Feb 15;198(3):1046-53. PMID:8117260 doi:10.1006/bbrc.1994.1149
- ↑ Oh Y, Nagalla SR, Yamanaka Y, Kim HS, Wilson E, Rosenfeld RG. Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II. J Biol Chem. 1996 Nov 29;271(48):30322-5. PMID:8939990 doi:10.1074/jbc.271.48.30322
