Synapsin

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spinqualitylabelsall models Rat synapsin 1 complex with ATP and Ca++ ion (green) (PDB code 1px2) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Structural highlights Function Synapsins (SYN) are neuronal phosphoproteins which modulate neurotransmitter release at the pre-synaptic terminal by reversibly tethering synaptic vescicles to the actin cytoskeleton[1]. Structural highlights The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the ATP which makes both and with the protein[2]. Water molecules are shown as red spheres.

3D structures of synapsin

Updated on 15-August-2024

References

1. ↑ Cesca F, Baldelli P, Valtorta F, Benfenati F. The synapsins: key actors of synapse function and plasticity. Prog Neurobiol. 2010 Aug;91(4):313-48. doi: 10.1016/j.pneurobio.2010.04.006. Epub, 2010 May 10. PMID:20438797 doi:http://dx.doi.org/10.1016/j.pneurobio.2010.04.006
2. ↑ Brautigam CA, Chelliah Y, Deisenhofer J. Tetramerization and ATP binding by a protein comprising the A, B, and C domains of rat synapsin I. J Biol Chem. 2004 Mar 19;279(12):11948-56. Epub 2003 Dec 19. PMID:14688264 doi:10.1074/jbc.M312015200