4qnn

Structural highlights

Function

PA1_VESBA Catalyzes the hydrolysis of phosphatidylcholine with phospholipase A1 activity (By similarity). Shows potent hemolytic activity that is responsible for its lethal effect (PubMed:26603193). May act as an allergen (By similarity). In vivo, induces local inflammatory effects (PubMed:7687388).[UniProtKB:P0DMB4]^{[1] [2]}

See Also

• Phospholipase A1

References

1. ↑ Ho CL, Hwang LL, Chen CT. Edema-inducing activity of a lethal protein with phospholipase A1 activity isolated from the black-bellied hornet (Vespa basalis) venom. Toxicon. 1993 May;31(5):605-13. PMID:7687388 doi:10.1016/0041-0101(93)90115-y
2. ↑ Hou MH, Chuang CY, Ko TP, Hu NJ, Chou CC, Shih YP, Ho CL, Wang AH. Crystal structure of vespid phospholipase A(1) reveals insights into the mechanism for cause of membrane dysfunction. Insect Biochem Mol Biol. 2016 Jan;68:79-88. PMID:26603193 doi:10.1016/j.ibmb.2015.11.002