Structural highlights
Function
INSRR_HUMAN Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.[1]
References
- ↑ Deyev IE, Sohet F, Vassilenko KP, Serova OV, Popova NV, Zozulya SA, Burova EB, Houillier P, Rzhevsky DI, Berchatova AA, Murashev AN, Chugunov AO, Efremov RG, Nikol'sky NN, Bertelli E, Eladari D, Petrenko AG. Insulin receptor-related receptor as an extracellular alkali sensor. Cell Metab. 2011 Jun 8;13(6):679-89. doi: 10.1016/j.cmet.2011.03.022. PMID:21641549 doi:http://dx.doi.org/10.1016/j.cmet.2011.03.022
