Structural highlights
Function
CHIL3_MOUSE Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy.[1] [2] [3]
References
- ↑ Owhashi M, Arita H, Hayai N. Identification of a novel eosinophil chemotactic cytokine (ECF-L) as a chitinase family protein. J Biol Chem. 2000 Jan 14;275(2):1279-86. PMID:10625674
- ↑ Chang NC, Hung SI, Hwa KY, Kato I, Chen JE, Liu CH, Chang AC. A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin. J Biol Chem. 2001 May 18;276(20):17497-506. Epub 2001 Jan 31. PMID:11297523 doi:http://dx.doi.org/10.1074/jbc.M010417200
- ↑ Harbord M, Novelli M, Canas B, Power D, Davis C, Godovac-Zimmermann J, Roes J, Segal AW. Ym1 is a neutrophil granule protein that crystallizes in p47phox-deficient mice. J Biol Chem. 2002 Feb 15;277(7):5468-75. Epub 2001 Dec 3. PMID:11733538 doi:http://dx.doi.org/10.1074/jbc.M110635200
