7bps

Structural highlights

Function

TX101_MOUSE Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct probably through molecule adhesion ADAM3 (PubMed:23633567, PubMed:23969891). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity).[UniProtKB:Q924B5]^{[1] [2]}

References

1. ↑ Fujihara Y, Tokuhiro K, Muro Y, Kondoh G, Araki Y, Ikawa M, Okabe M. Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8111-6. PMID:23633567 doi:10.1073/pnas.1222166110
2. ↑ Li W, Guo XJ, Teng F, Hou XJ, Lv Z, Zhou SY, Bi Y, Wan HF, Feng CJ, Yuan Y, Zhao XY, Wang L, Sha JH, Zhou Q. Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice. J Mol Cell Biol. 2013 Oct;5(5):345-7. PMID:23969891 doi:10.1093/jmcb/mjt031