Structural highlights
Function
HEXNO_RALSU Catalyzes the oxidation of a range of monosaccharides in vitro, displaying the highest activity with N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc), with a reduction of O2 to H2O2. Acts upon the C1 carbon of the GlcNAc or GalNAc molecule, producing the corresponding lactone, which can spontaneously hydrolyze. Its biological function is unclear, but its main function might be connected to extracellular production of hydrogen peroxide to compete with other organisms through oxidative stress, or support the action of peroxidases and peroxygenases.[1]
References
- ↑ Rembeza E, Boverio A, Fraaije MW, Engqvist MKM. Discovery of Two Novel Oxidases Using a High-Throughput Activity Screen. Chembiochem. 2022 Jan 19;23(2):e202100510. doi: 10.1002/cbic.202100510. Epub 2021, Nov 18. PMID:34709726 doi:http://dx.doi.org/10.1002/cbic.202100510
