8gnk

Structural highlights

Function

SC6A1_RAT Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:1975955, PubMed:18054861). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (PubMed:18054861, PubMed:21775701). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (PubMed:18054861, PubMed:21775701). Also mediates sodium- and chloride-dependent transport of hypotaurine (By similarity).[UniProtKB:P31648]^{[1] [2] [3]}

References

1. ↑ Wu Y, Wang W, Díez-Sampedro A, Richerson GB. Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1. Neuron. 2007 Dec 6;56(5):851-65. PMID:18054861 doi:10.1016/j.neuron.2007.10.021
2. ↑ Guastella J, Nelson N, Nelson H, Czyzyk L, Keynan S, Miedel MC, Davidson N, Lester HA, Kanner BI. Cloning and expression of a rat brain GABA transporter. Science. 1990 Sep 14;249(4974):1303-6. PMID:1975955 doi:10.1126/science.1975955
3. ↑ Bertram S, Cherubino F, Bossi E, Castagna M, Peres A. GABA reverse transport by the neuronal cotransporter GAT1: influence of internal chloride depletion. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1064-73. PMID:21775701 doi:10.1152/ajpcell.00120.2011