8qec

Structural highlights

Function

NPC1_YEAST Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments.^{[1] [2]}

References

1. ↑ Malathi K, Higaki K, Tinkelenberg AH, Balderes DA, Almanzar-Paramio D, Wilcox LJ, Erdeniz N, Redican F, Padamsee M, Liu Y, Khan S, Alcantara F, Carstea ED, Morris JA, Sturley SL. Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution. J Cell Biol. 2004 Feb 16;164(4):547-56. PMID:14970192 doi:http://dx.doi.org/10.1083/jcb.200310046
2. ↑ Berger AC, Hanson PK, Wylie Nichols J, Corbett AH. A yeast model system for functional analysis of the Niemann-Pick type C protein 1 homolog, Ncr1p. Traffic. 2005 Oct;6(10):907-17. PMID:16138904 doi:http://dx.doi.org/TRA327