8tj2

Structural highlights

Function

PILA_MYXXD Major component of the type IV pili that are required for social gliding motility through cycles of extension and retraction. Extended pili are composed of thousands of copies of PilA and retract upon binding to extracellular polysaccharides and thereby pull the cell forward.^{[1] [2] [3] [4]}

See Also

• Pilin 3D structures

References

1. ↑ Yang Z, Lux R, Hu W, Hu C, Shi W. PilA localization affects extracellular polysaccharide production and fruiting body formation in Myxococcus xanthus. Mol Microbiol. 2010 Jun;76(6):1500-13. PMID:20444090 doi:10.1111/j.1365-2958.2010.07180.x
2. ↑ Yang Z, Hu W, Chen K, Wang J, Lux R, Zhou ZH, Shi W. Alanine 32 in PilA is important for PilA stability and type IV pili function in Myxococcus xanthus. Microbiology (Reading). 2011 Jul;157(Pt 7):1920-1928. PMID:21493683 doi:10.1099/mic.0.049684-0
3. ↑ Wu SS, Kaiser D. Genetic and functional evidence that Type IV pili are required for social gliding motility in Myxococcus xanthus. Mol Microbiol. 1995 Nov;18(3):547-58. PMID:8748037 doi:10.1111/j.1365-2958.1995.mmi_18030547.x
4. ↑ Wu SS, Kaiser D. Regulation of expression of the pilA gene in Myxococcus xanthus. J Bacteriol. 1997 Dec;179(24):7748-58. PMID:9401034 doi:10.1128/jb.179.24.7748-7758.1997