| Structural highlights
Function
LPLT1_CAEEL Has a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. Required for the alignment of the mitotic spindles and division planes. May have a role in cell death events. Required for normal defection and oocyte fertilization. Involved in sperm function. Operates in pharyngeal pumping during feeding.[1] [2] [3] [4] [5]
References
- ↑ Mee CJ, Tomlinson SR, Perestenko PV, De Pomerai D, Duce IR, Usherwood PN, Bell DR. Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegans. Biochem J. 2004 Feb 15;378(Pt 1):185-91. PMID:14594448 doi:10.1042/BJ20031213
- ↑ Willson J, Amliwala K, Davis A, Cook A, Cuttle MF, Kriek N, Hopper NA, O'Connor V, Harder A, Walker RJ, Holden-Dye L. Latrotoxin receptor signaling engages the UNC-13-dependent vesicle-priming pathway in C. elegans. Curr Biol. 2004 Aug 10;14(15):1374-9. PMID:15296755 doi:10.1016/j.cub.2004.07.056
- ↑ Guest M, Bull K, Walker RJ, Amliwala K, O'Connor V, Harder A, Holden-Dye L, Hopper NA. The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans. Int J Parasitol. 2007 Dec;37(14):1577-88. PMID:17583712 doi:10.1016/j.ijpara.2007.05.006
- ↑ Langenhan T, Prömel S, Mestek L, Esmaeili B, Waller-Evans H, Hennig C, Kohara Y, Avery L, Vakonakis I, Schnabel R, Russ AP. Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. Dev Cell. 2009 Oct;17(4):494-504. PMID:19853563 doi:10.1016/j.devcel.2009.08.008
- ↑ Prömel S, Frickenhaus M, Hughes S, Mestek L, Staunton D, Woollard A, Vakonakis I, Schöneberg T, Schnabel R, Russ AP, Langenhan T. The GPS motif is a molecular switch for bimodal activities of adhesion class G protein-coupled receptors. Cell Rep. 2012 Aug 30;2(2):321-31. PMID:22938866 doi:10.1016/j.celrep.2012.06.015
|
