4f8b

Structural highlights

Function

QUEF_BACSU Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1), a late step in the queuosine pathway.^{[1] [2]}

References

1. ↑ Van Lanen SG, Reader JS, Swairjo MA, de Crecy-Lagard V, Lee B, Iwata-Reuyl D. From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4264-9. Epub 2005 Mar 14. PMID:15767583 doi:http://dx.doi.org/0408056102
2. ↑ Lee BW, Van Lanen SG, Iwata-Reuyl D. Mechanistic studies of Bacillus subtilis QueF, the nitrile oxidoreductase involved in queuosine biosynthesis. Biochemistry. 2007 Nov 6;46(44):12844-54. Epub 2007 Oct 11. PMID:17929836 doi:http://dx.doi.org/10.1021/bi701265r