1npl

Structural highlights

Function

LEC_NARPS D-mannose-binding lectin which binds alpha-D-linked mannose (PubMed:10388566, PubMed:1874921, PubMed:14505313, PubMed:2350177, PubMed:1645507). Displays a high affinity for alpha-(1-6)-mannose oligomers (PubMed:2350177, PubMed:1645507). Able to interact with both terminal and internal alpha-D-mannosyl residues (PubMed:2350177). Displays antiviral activity and therefore may contribute to defense against infections (PubMed:1645507, PubMed:7481093).^{[1] [2] [3] [4] [5] [6]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Agglutinin 3D structures

References

1. ↑ Sauerborn MK, Wright LM, Reynolds CD, Grossmann JG, Rizkallah PJ. Insights into carbohydrate recognition by Narcissus pseudonarcissus lectin: the crystal structure at 2 A resolution in complex with alpha1-3 mannobiose. J Mol Biol. 1999 Jul 2;290(1):185-99. PMID:10388566 doi:10.1006/jmbi.1999.2862
2. ↑ Heyder P, Gaipl US, Beyer TD, Voll RE, Kern PM, Stach C, Kalden JR, Herrmann M. Early detection of apoptosis by staining of acid-treated apoptotic cells with FITC-labeled lectin from Narcissus pseudonarcissus. Cytometry A. 2003 Oct;55(2):86-93. PMID:14505313 doi:10.1002/cyto.a.10078
3. ↑ Balzarini J, Schols D, Neyts J, Van Damme E, Peumans W, De Clercq E. Alpha-(1-3) inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro. Antimicrob Agents Chemother. 1991 Mar;35(3):410-6. PMID:1645507 doi:10.1128/AAC.35.3.410
4. ↑ Weiler BE, Schäcke H, Bachmann M, Brigido L, Gilbert M, Mills J, Matthes E, Forrest JM, Müller WE. Human immunodeficiency virus: novel enzyme-linked immunoassays for quantitation of envelope glycoprotein 120. J Virol Methods. 1991 May;32(2-3):287-301. PMID:1874921 doi:10.1016/0166-0934(91)90059-9
5. ↑ Kaku H, Van Damme EJ, Peumans WJ, Goldstein IJ. Carbohydrate-binding specificity of the daffodil (Narcissus pseudonarcissus) and amaryllis (Hippeastrum hybr.) bulb lectins. Arch Biochem Biophys. 1990 Jun;279(2):298-304. PMID:2350177 doi:10.1016/0003-9861(90)90495-k
6. ↑ Marchetti M, Mastromarino P, Rieti S, Seganti L, Orsi N. Inhibition of herpes simplex, rabies and rubella viruses by lectins with different specificities. Res Virol. 1995 May-Jun;146(3):211-5. PMID:7481093 doi:10.1016/0923-2516(96)80581-4