2n0v

Publication Abstract from PubMed

Multifunctional and promiscuous antimicrobial peptides (AMPs) can be used as an efficient strategy to control pathogens. However, little is known about the structural properties of plant promiscuous AMPs without disulfide bonds. CD and NMR were used to elucidate the structure of the promiscuous peptide Cn-AMP1, a disulfide-free peptide isolated from green coconut water. Data here reported shows that peptide structure is transitory and could be different according to the micro-environment. In this regard, Cn-AMP1 showed a random coil in a water environment and an alpha-helical structure in the presence of SDS-d25 micelles. Moreover, deuterium exchange experiments showed that Gly4, Arg5 and Met9 residues are less accessible to solvent, suggesting that flexibility and cationic charges seem to be essential for Cn-AMP1 multiple activities.

Structural insights into Cn-AMP1, a short disulfide-free multifunctional peptide from green coconut water.,Santana MJ, de Oliveira AL, Queiroz Junior LH, Mandal SM, Matos CO, Dias Rde O, Franco OL, Liao LM FEBS Lett. 2015 Feb 27;589(5):639-44. doi: 10.1016/j.febslet.2015.01.029. Epub, 2015 Jan 29. PMID:25639464^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.