Structural highlights
Function
Q991S8_9FLAV Acts as a cofactor for the NS3 protease activity.[ARBA:ARBA00023576] Leader cysteine autoprotease that cleaves itself from the nascent polyprotein during translation of the viral mRNA. Once released, plays a role in the inhibition of host innate immune response by interacting with host IRF3 and inducing its proteasomal degradation.[ARBA:ARBA00023578] Packages viral RNA to form a viral nucleocapsid and thereby protects viral RNA. Also plays a role in transcription regulation. Protects the incoming virus against IFN-induced effectors.[ARBA:ARBA00034097] Plays a role in the regulation of viral RNA replication.[ARBA:ARBA00023574]
