8c8h

Structural highlights

Function

RP22_VACCW Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:31835031). Responsible for the transcription of early, intermediate and late genes. DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG133, thereby allowing the early genes transcription. Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.^{[1] [2]}

References

1. ↑ Yang Z, Moss B. Interaction of the vaccinia virus RNA polymerase-associated 94-kilodalton protein with the early transcription factor. J Virol. 2009 Dec;83(23):12018-26. PMID:19759131 doi:10.1128/JVI.01653-09
2. ↑ Hillen HS, Bartuli J, Grimm C, Dienemann C, Bedenk K, Szalay AA, Fischer U, Cramer P. Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes. Cell. 2019 Dec 12;179(7):1525-1536.e12. doi: 10.1016/j.cell.2019.11.023. PMID:31835031 doi:http://dx.doi.org/10.1016/j.cell.2019.11.023