Semaglutide

From Proteopedia

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Semaglutide is an analog of the GLP-1 (glucagon-like peptide-1) hormone. It acts as an agonist to the GLP-1 receptor and is used as drug to manage diabetes. Its use has been growing as a weight-loss medication, and potential benefits across a wide range of diseases is currently studied.

Contents 1 Discovery 2 Structure 3 Effects of receptor binding 4 Side effects 5 References

Discovery

Semaglutide was discovered ^[1] in an effort to increase the lifetime of a once-a-day medication called Liraglutide. It is derived from the GLP-1 hormone, contains two amino acid sequence changes and a covalently attached lipid.

Structure

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image The peptide forms a single alpha helix, just like GLP-1. Binding to receptor

Effects of receptor binding

Side effects

References

1. ↑ Lau J, Bloch P, Schaffer L, Pettersson I, Spetzler J, Kofoed J, Madsen K, Knudsen LB, McGuire J, Steensgaard DB, Strauss HM, Gram DX, Knudsen SM, Nielsen FS, Thygesen P, Reedtz-Runge S, Kruse T. The discovery of the once weekly glucagon like peptide 1 (GLP-1) analog semaglutide. J Med Chem. 2015 Aug 26. PMID:26308095 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b00726