3ubu

Structural highlights

Function

[SLA1_DEIAC] Agglucetin specifically causes platelet aggregation and surface exposure of integrin alpha-IIb/beta-3 with a GPIb-(GP1BA-) dependent manner in washed platelets. It binds to human platelets in a saturable manner, and its binding is specifically blocked by anti-GP Ib mAb. It regulates endothelial cell survival and promotes angiogenesis by activating integrin alpha-v/beta-3 signaling through FAK/phosphatidylinositol 3-kinase (PI3K)/Akt pathway.^{[1] [2]} [SLB2_DEIAC] Agglucetin specifically causes platelet aggregation and surface exposure of integrin alpha-IIb/beta-3 with a GPIb-(GP1BA-) dependent manner in washed platelets. It binds to human platelets in a saturable manner, and its binding is specifically blocked by anti-GP Ib mAb. It regulates endothelial cell survival and promotes angiogenesis by activating integrin alpha-v/beta-3 signaling through FAK/phosphatidylinositol 3-kinase (PI3K)/Akt pathway.^{[3] [4]}

References

1. ↑ Wang WJ, Huang TF. A novel tetrameric venom protein, agglucetin from Agkistrodon acutus, acts as a glycoprotein Ib agonist. Thromb Haemost. 2001 Oct;86(4):1077-86. PMID:11686327
2. ↑ Wang WJ. Agglucetin, a tetrameric C-type lectin-like venom protein, regulates endothelial cell survival and promotes angiogenesis by activating integrin alphavbeta3 signaling. Biochem Biophys Res Commun. 2008 May 2;369(2):753-60. doi:, 10.1016/j.bbrc.2008.02.091. Epub 2008 Feb 27. PMID:18312855 doi:http://dx.doi.org/10.1016/j.bbrc.2008.02.091
3. ↑ Wang WJ, Huang TF. A novel tetrameric venom protein, agglucetin from Agkistrodon acutus, acts as a glycoprotein Ib agonist. Thromb Haemost. 2001 Oct;86(4):1077-86. PMID:11686327
4. ↑ Wang WJ. Agglucetin, a tetrameric C-type lectin-like venom protein, regulates endothelial cell survival and promotes angiogenesis by activating integrin alphavbeta3 signaling. Biochem Biophys Res Commun. 2008 May 2;369(2):753-60. doi:, 10.1016/j.bbrc.2008.02.091. Epub 2008 Feb 27. PMID:18312855 doi:http://dx.doi.org/10.1016/j.bbrc.2008.02.091
5. ↑ Gao Y, Ge H, Chen H, Li H, Liu Y, Chen L, Li X, Liu J, Niu L, Teng M. Crystal structure of agkisacucetin, a Gpib-binding snake C-type lectin that inhibits platelet adhesion and aggregation. Proteins. 2012 Feb 22. doi: 10.1002/prot.24060. PMID:22447656 doi:10.1002/prot.24060