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This Sandbox is Reserved from March 18 through September 1, 2025 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson and Mark Macbeth at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1828 through Sandbox Reserved 1846.

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Contents 1 Leaf Branch Compost Cutinase 1.1 Introduction 1.2 Function 1.3 Relevance 1.3.1 Plastic Pollution 1.3.2 PET Depolymerization 1.4 Structural Overview 1.4.1 Catalytic Triad 1.4.2 Ligand Binding Pocket 1.5 Mutation Sites of Interest 1.5.1 F243 1.5.2 T96 1.5.3 Y127 1.5.4 N246 1.5.5 S283 & D238 1.6 References 1.7 Student Contributors

Leaf Branch Compost Cutinase

Rebecca Hoff/Sandbox 1

Introduction

^[1]

Function

Relevance

Plastic Pollution

PET Depolymerization

Structural Overview

Catalytic Triad

Ligand Binding Pocket

Mutation Sites of Interest

F243

T96

Y127

N246

S283 & D238

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References

1. ↑ Tournier V, Topham CM, Gilles A, David B, Folgoas C, Moya-Leclair E, Kamionka E, Desrousseaux ML, Texier H, Gavalda S, Cot M, Guemard E, Dalibey M, Nomme J, Cioci G, Barbe S, Chateau M, Andre I, Duquesne S, Marty A. An engineered PET depolymerase to break down and recycle plastic bottles. Nature. 2020 Apr;580(7802):216-219. doi: 10.1038/s41586-020-2149-4. Epub 2020 Apr, 8. PMID:32269349 doi:http://dx.doi.org/10.1038/s41586-020-2149-4

Student Contributors

Ashley Callaghan Rebecca Hoff Simone McCowan