Relevance and Disease
Lung cancer is the leading cause of cancer related death worldwide. In the United States alone, over 120,000 deaths were caused by lung cancer in 2024[1]. Non small cell lung cancer make up approximately 84% of all lung cancer cases, and of these lung adenocarcinoma accounts for about 65%[2]. In lung adenocarcinoma, STK11 is the third most commonly mutated gene, behind only KRAS and p53[3]
Structural Highlights
The heterotrimeric complex is composed of
References
- ↑ https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2024/2024-cancer-facts-and-figures-acs.pdf
- ↑ 10.1001/jamaoncol.2021.4932
- ↑ 10.1091/mbc.E15-08-0569.
