Function
is a highly glycosylated multifunctional cell surface receptor that is involved in cell-cell interaction and maintenance of the extracellular matrix.[1] The primary ligand for CD44 is hyaluronan (HA), but it has also been found to interact with other molecules including osteopontin (OPN), collagens, and fibronectin. [2] CD44 is a single chain protein containing four distinct regions: the N-terminal HA binding Link domain[3], a flexible variable domain, a transmembrane domain, and an intracellular signaling domain.[4] The is an approximately 100 amino acid domain consisting of two antiparallel β-sheets, two α-helicies, and two disulfide bonds.[5] This domain is found in most HA binding proteins, including aggrecan, versican, brevican, and tumor necrosis factor-inducible gene 6.[6]
Evolutionary Conservation
of CD44 residues, as determined by ConSurfDB.
You may read the explanation
of the method and the full data available from
ConSurf.
Isoforms
Substrate Binding
Cancer
