6mzc

Structural highlights

Disease

TAF2_HUMAN Microcephaly-thin corpus callosum-intellectual disability syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

TAF2_HUMAN Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter.^{[1] [2]}

See Also

• Transcription initiation factors 3D structures

References

1. ↑ Kaufmann J, Ahrens K, Koop R, Smale ST, Muller R. CIF150, a human cofactor for transcription factor IID-dependent initiator function. Mol Cell Biol. 1998 Jan;18(1):233-9. PMID:9418870
2. ↑ Martinez E, Ge H, Tao Y, Yuan CX, Palhan V, Roeder RG. Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex. Mol Cell Biol. 1998 Nov;18(11):6571-83. PMID:9774672