2c62

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Image:2c62.gif

2c62, resolution 1.74Å

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CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION COFACTOR PC4 IN COMPLEX WITH SINGLE-STRANDED DNA

Overview

The 1.74-A crystal structure of the human transcription cofactor PC4 in, complex with a single-stranded 20-mer oligonucleotide reveals how, symmetry-related beta-surfaces of the protein homodimer interact with, juxtaposed 5-nucleotide DNA regions running in opposite directions. The, structure explains high-affinity binding of PC4 to the complementary, strands of unwinding duplex DNA, and it suggests the cofactor may have a, role in relaxing negative supercoils or exposing unpaired bases for, sequence-specific recognition by other biomolecules.

About this Structure

2C62 is a Single protein structure of sequence from Homo sapiens with SO4 as ligand. Structure known Active Site: AC1. Full crystallographic information is available from OCA.

Reference

A global transcription cofactor bound to juxtaposed strands of unwound DNA., Werten S, Moras D, Nat Struct Mol Biol. 2006 Feb;13(2):181-2. Epub 2006 Jan 15. PMID:16415882

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