2a4g
From Proteopedia
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| , resolution 2.50Å | |||||||
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| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound
Overview
We have discovered that introduction of appropriate amino acid derivatives at P'2 position improved the binding potency of P3-capped alpha-ketoamide inhibitors of HCV NS3 serine protease. X-ray crystal structure of one of the inhibitors (43) bound to the protease revealed the importance of the P'2 moiety.
About this Structure
2A4G is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.
Reference
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency., Arasappan A, Njoroge FG, Chan TY, Bennett F, Bogen SL, Chen K, Gu H, Hong L, Jao E, Liu YT, Lovey RG, Parekh T, Pike RE, Pinto P, Santhanam B, Venkatraman S, Vaccaro H, Wang H, Yang X, Zhu Z, Mckittrick B, Saksena AK, Girijavallabhan V, Pichardo J, Butkiewicz N, Ingram R, Malcolm B, Prongay A, Yao N, Marten B, Madison V, Kemp S, Levy O, Lim-Wilby M, Tamura S, Ganguly AK, Bioorg Med Chem Lett. 2005 Oct 1;15(19):4180-4. PMID:16087332
Page seeded by OCA on Mon Mar 31 01:47:44 2008
Categories: Hepatitis c virus | Protein complex | Arasappan, A. | Bennett, F. | Bogen, S L. | Butkiewicz, N. | Chan, T Y. | Chen, K. | Ganguly, A K. | Girijavallabhan, V. | Gu, H. | Hong, L. | Ingram, R. | Jao, E. | Kemp, S. | Levy, O. | Lim-Wilby, M. | Liu, Y T. | Lovey, R G. | Malcolm, B. | Marten, B. | Mckittrick, B. | Njoroge, F G. | Parekh, T. | Pichardo, J. | Pike, R E. | Pinto, P. | Prongay, A J. | Saksena, A K. | Santhanam, B. | Tamura, S. | V., Madison | Vaccaro, H. | Venkatraman, S. | Wang, H. | Yang, X. | Yao, N. | Zhu, Z. | Virus/viral protein
