2b07
From Proteopedia
| |||||||
| , resolution 2.1Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | PTPN1, PTP1B (Homo sapiens) | ||||||
| Activity: | Protein-tyrosine-phosphatase, with EC number 3.1.3.48 | ||||||
| Related: | 2AZR
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.
Overview
A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crystallography and molecular modeling. Excellent consistency has been observed between structure-activity relationships and structural information from PTP1B-inhibitor complexes.
About this Structure
2B07 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors., Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J, Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. Epub 2005 Nov 21. PMID:16303309
Page seeded by OCA on Mon Mar 31 01:59:43 2008
Categories: Homo sapiens | Protein-tyrosine-phosphatase | Single protein | Binnun, E. | Erbe, D V. | Follows, B C. | Foreman, K. | Joseph-McCarthy, D. | Kirincich, S J. | Lee, J. | Moretto, A F. | Smith, M J. | Tam, S K. | Tam, S Y. | Wan, Z K. | Wilson, D P. | Xu, W X. | Zhang, Y L. | Hydrolyase | Protein tyrosine phosphatase | Tricyclic thiophene
