2c4g
From Proteopedia
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| , resolution 2.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , | ||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514
Overview
We have recently reported about a new class of Aurora-A inhibitors based on a bicyclic tetrahydropyrrolo[3,4-c]pyrazole scaffold. Here we describe the synthesis and early expansion of CDK2/cyclin A-E inhibitors belonging to the same chemical class. Synthesis of the compounds was accomplished using a solution-phase protocol amenable to rapid parallel expansion. Compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit CDK2-mediated tumor cell proliferation have been obtained.
About this Structure
2C4G is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors., Pevarello P, Fancelli D, Vulpetti A, Amici R, Villa M, Pittala V, Vianello P, Cameron A, Ciomei M, Mercurio C, Bischoff JR, Roletto F, Varasi M, Brasca MG, Bioorg Med Chem Lett. 2006 Feb 15;16(4):1084-90. Epub 2005 Nov 14. PMID:16290148
Page seeded by OCA on Mon Mar 31 02:16:08 2008
Categories: Homo sapiens | Non-specific serine/threonine protein kinase | Protein complex | Amici, R. | Bischoff, J R. | Brasca, M G. | Cameron, A. | Ciomei, M. | Fancelli, D. | Fogliatto, G. | Mercurio, C. | Pevarello, P. | Pittala, V. | Roletto, F. | Varasi, M. | Villa, M. | Vulpetti, A. | Atp-binding | Cell cycle | Cell division | Cyclin | Mitosis | Nucleotide-binding | Phosphorylation | Polymorphism | Protein kinase | Serine/threonine-protein kinase | Transferase
