2fau
From Proteopedia
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| , resolution 2.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | VPS26A, VPS26 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of human vps26
Overview
The mammalian retromer complex consists of SNX1, SNX2, Vps26, Vps29 and Vps35, and retrieves lysosomal enzyme receptors from endosomes to the trans-Golgi network. The structure of human Vps26A at 2.1-A resolution reveals two curved beta-sandwich domains connected by a polar core and a flexible linker. Vps26 has an unpredicted structural relationship to arrestins. The Vps35-binding site on Vps26 maps to a mobile loop spanning residues 235-246, near the tip of the C-terminal domain. The loop is phylogenetically conserved and provides a mechanism for Vps26 integration into the complex that leaves the rest of the structure free for engagements with membranes and for conformational changes. Hydrophobic residues and a glycine in this loop are required for integration into the retromer complex and endosomal localization of human Vps26, and for the function of yeast Vps26 in carboxypeptidase Y sorting.
About this Structure
2FAU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain., Shi H, Rojas R, Bonifacino JS, Hurley JH, Nat Struct Mol Biol. 2006 Jun;13(6):540-8. Epub 2006 May 28. PMID:16732284
Page seeded by OCA on Mon Mar 31 03:00:11 2008
