2uzg

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Image:2uzg.jpg


PDB ID 2uzg

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Ligands:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



ZF-UBP DOMAIN OF VDU1


Overview

USP33/VDU1 is a deubiquitinating enzyme that binds to the von Hippel-Lindau tumor suppressor protein. It also regulates thyroid hormone activation by deubiquitinating type 2 iodothyronine deiodinase. USP33/VDU1 contains a ZF UBP domain, a protein module found in many proteins in the ubiquitin-proteasome system. Several ZF UBP domains have been shown to bind ubiquitin, and a structure of a complex of the ZF UBP domain of isoT/USP5 and ubiquitin is available. In the present work, the solution structure of the ZF UBP domain of USP33/VDU1 has been determined by NMR spectroscopy. The structure differs from that of the USP5 domain, which contains only one of the three Zn ions present in the USP33/VDU1 structure. The USP33/VDU1 ZnF UBP domain does not bind to ubiquitin.

About this Structure

2UZG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The solution structure of the ZnF UBP domain of USP33/VDU1., Allen MD, Bycroft M, Protein Sci. 2007 Sep;16(9):2072-5. PMID:17766394

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