2ver

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models PDB ID 2ver Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
Sites:	, and
Ligands:
Related:	1E07, 1UT2, 1USZ, 2IXQ, 1RXL
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

STRUCTURAL MODEL FOR THE COMPLEX BETWEEN THE DR ADHESINS AND CARCINOEMBRYONIC ANTIGEN (CEA)

Overview

Carcinoembryonic antigen (CEA)-related cell adhesion molecules (CEACAMs) are host receptors for the Dr family of adhesins of Escherichia coli. To define the mechanism for binding of Dr adhesins to CEACAM receptors, we carried out structural studies on the N-terminal domain of CEA and its complex with the Dr adhesin. The crystal structure of CEA reveals a dimer similar to other dimers formed by receptors with IgV-like domains. The structure of the CEA/Dr adhesin complex is proposed based on NMR spectroscopy and mutagenesis data in combination with biochemical characterization. The Dr adhesin/CEA interface overlaps appreciably with the region responsible for CEA dimerization. Binding kinetics, mutational analysis and spectroscopic examination of CEA dimers suggest that Dr adhesins can dissociate CEA dimers prior to the binding of monomeric forms. Our conclusions include a plausible mechanism for how E. coli, and perhaps other bacterial and viral pathogens, exploit CEACAMs. The present structure of the complex provides a powerful tool for the design of novel inhibitory strategies to treat E. coli infections.

About this Structure

2VER is a Protein complex structure of sequences from Escherichia coli and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation., Korotkova N, Yang Y, Le Trong I, Cota E, Demeler B, Marchant J, Thomas WE, Stenkamp RE, Moseley SL, Matthews S, Mol Microbiol. 2008 Jan;67(2):420-34. Epub 2007 Dec 11. PMID:18086185

Page seeded by OCA on Mon Mar 31 05:11:22 2008