2vlk

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spinqualitylabelsall models PDB ID 2vlk Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 2.50Å
Related:	2VLR, 2VLL, 2VLM, 2VLJ, 1UQS, 1BD2, 2AK4, 1YPZ, 1IM3, 1UXW, 1I7U, 1C16, 1HSA, 2AXF, 1GZP, 2BNQ, 1W72, 2JCC, 2BCK, 1DE4, 1N2R, 1EXU, 1QRN, 2HLA, 1MHE, 1IM9, 1EEZ, 1JHT, 1QQD, 1QR1, 1ZS8, 1HLA, 1JGD, 1I1Y, 1VGK, 1AGE, 1UR7, 1HHG, 1S9X, 1A9E, 1DUZ, 2CLR, 3HLA, 1M05, 1TVB, 2V2W, 1ONQ, 1A1N, 1LP9, 1ZSD, 1M6O, 2BSU, 1HHK, 1ZT4, 1HSB, 1X7Q, 1CE6, 1PY4, 1SYV, 2J8U, 1SYS, 1OGT, 1CG9, 1P7Q, 1Q94, 1JNJ, 1AGB, 2D31, 1AQD, 1XZ0, 1LDS, 1HHH, 1TVH, 1XR8, 2BSS, 1A1M, 1E28, 2V2X, 1XR9, 2GJ6, 1EFX, 1QLF, 2AV1, 1TMC, 1QSF, 1DUY, 1JGE, 1KPR, 2HJL, 1QEW, 1W0V, 1K5N, 1AO7, 2BNR, 1XH3, 2BST, 1MI5, 2H26, 1S9Y, 1A1O, 1AGF, 2A83, 1OGA, 2F8O, 2BSV, 2CII, 1I7R, 1JF1, 2C7U, 2F74, 1E27, 1W0W, 1GZQ, 1UXS, 1AKJ, 2HJK, 2VB5, 1AGD, 1R3H, 1EEY, 1I7T, 1I4F, 1YDP, 2BSR, 1B0G, 1B0R, 1OF2, 1HHI, 1QSE, 1A9B, 2AXG, 2BVQ, 1AGC, 1HHJ, 1QVO, 1S9W, 1KTL, 1A6Z, 2CIK, 2UWE, 1I1F, 2AV7
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

THE STRUCTURAL DYNAMICS AND ENERGETICS OF AN IMMUNODOMINANT T-CELL RECEPTOR ARE PROGRAMMED BY ITS VBETA DOMAIN

Overview

Immunodominant and public T cell receptor (TCR) usage is relatively common in many viral diseases yet surprising in the context of the large naive TCR repertoire. We examined the highly conserved Vbeta17:Valpha10.2 JM22 T cell response to the influenza matrix peptide (58-66)-HLA-A( *)0201 (HLA-A2-flu) through extensive kinetic, thermodynamic, and structural analyses. We found several conformational adjustments that accompany JM22-HLA-A2-flu binding and identified a binding "hotspot" within the Vbeta domain of the TCR. Within this hotspot, key germline-encoded CDR1 and CDR2 loop residues and a crucial but commonly coded residue in the hypervariable region of CDR3 provide the basis for the substantial bias in the selection of the germline-encoded Vbeta17 domain. The chances of having a substantial number of T cells in the naive repertoire that have HLA-A2-flu-specific Vbeta17 receptors may consequently be relatively high, thus explaining the immunodominant usage of this clonotype.

About this Structure

2VLK is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain., Ishizuka J, Stewart-Jones GB, van der Merwe A, Bell JI, McMichael AJ, Jones EY, Immunity. 2008 Feb;28(2):171-82. PMID:18275829

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