1sg1
From Proteopedia
Crystal Structure of the Receptor-Ligand Complex between Nerve Growth Factor and the Common Neurotrophin Receptor p75
Contents |
Overview
Neurotrophins are secreted growth factors critical for the development and maintenance of the vertebrate nervous system. Neurotrophins activate two types of cell surface receptors, the Trk receptor tyrosine kinases and the shared p75 neurotrophin receptor. We have determined the 2.4 A crystal structure of the prototypic neurotrophin, nerve growth factor (NGF), complexed with the extracellular domain of p75. Surprisingly, the complex is composed of an NGF homodimer asymmetrically bound to a single p75. p75 binds along the homodimeric interface of NGF, which disables NGF's symmetry-related second p75 binding site through an allosteric conformational change. Thus, neurotrophin signaling through p75 may occur by disassembly of p75 dimers and assembly of asymmetric 2:1 neurotrophin/p75 complexes, which could potentially engage a Trk receptor to form a trimolecular signaling complex.
Disease
Known disease associated with this structure: Neuropathy, hereditary sensory and autonomic, type V OMIM:[162030]
About this Structure
1SG1 is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. The following page contains interesting information on the relation of 1SG1 with [Neurotrophins]. Full crystallographic information is available from OCA.
Reference
Structure of nerve growth factor complexed with the shared neurotrophin receptor p75., He XL, Garcia KC, Science. 2004 May 7;304(5672):870-5. PMID:15131306 Page seeded by OCA on Sat May 3 08:39:23 2008
