1a6a

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Image:1a6a.gif

Template:STRUCTURE 1a6a

THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3


Overview

A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes. The structure shows that the CLIP fragment binds to DR3 in a way almost identical to that in which antigenic peptides bind class II histocompatibility glycoproteins. The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM.

About this Structure

1A6A is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3., Ghosh P, Amaya M, Mellins E, Wiley DC, Nature. 1995 Nov 30;378(6556):457-62. PMID:7477400 Page seeded by OCA on Fri May 2 09:52:33 2008

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