1ad5

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Template:STRUCTURE 1ad5

SRC FAMILY KINASE HCK-AMP-PNP COMPLEX


Overview

The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

About this Structure

1AD5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658 Page seeded by OCA on Fri May 2 10:07:08 2008

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