1fbv
From Proteopedia
STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES
Overview
Ubiquitin-protein ligases (E3s) regulate diverse cellular processes by mediating protein ubiquitination. The c-Cbl proto-oncogene is a RING family E3 that recognizes activated receptor tyrosine kinases, promotes their ubiquitination by a ubiquitin-conjugating enzyme (E2) and terminates signaling. The crystal structure of c-Cbl bound to a cognate E2 and a kinase peptide shows how the RING domain recruits the E2. A comparison with a HECT family E3-E2 complex indicates that a common E2 motif is recognized by the two E3 families. The structure reveals a rigid coupling between the peptide binding and the E2 binding domains and a conserved surface channel leading from the peptide to the E2 active site, suggesting that RING E3s may function as scaffolds that position the substrate and the E2 optimally for ubiquitin transfer.
About this Structure
1FBV is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases., Zheng N, Wang P, Jeffrey PD, Pavletich NP, Cell. 2000 Aug 18;102(4):533-9. PMID:10966114 Page seeded by OCA on Fri May 2 16:08:45 2008
Categories: Homo sapiens | Protein complex | Ubiquitin--protein ligase | Jeffrey, P D. | Pavletich, N P. | Wang, P. | Zheng, N. | Cbl | E2 | E3 | Phosphorylation | Protein degradation | Tyrosine kinase | Ubch7 | Ubiquitin | Ubiquitination | Zap-70
